I tried, but, _____, to persuade Holmes to change his mind. He was too stubborn.

A. at ease
B. in trouble
C. by design
D. in vain
D
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I tried, but, _____, to persuade Holmes to change his mind He was too stubborn.

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B. in trouble
C. by design
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I tried, but, ________, to persuade Holmes to change his mind He was too stubborn．


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