—John, ______ do you visit your grandparents?
—Once a week.
A．how longB．how soon
C．how oftenD．how much
C
how long多長(zhǎng)；how soon多久；how often多久一次；how much多少錢。根據(jù)下文，每周一次。可知上文提問(wèn)頻率，故選C。
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